Wednesday, February 9, 2022

Vitamin D and heart disease

Vitamin D is created when people are exposed to sunlight and is also absorbed from the gastrointestinal tract. Both sources are activated in the liver to 25(OH)D and in the kidney to 1,25-dihydroxyvitamin D[1,25(OH)2D]; the 25(OH)D level has a half-life of 2–3 weeks and is a measure of vitamin D status.

Although vitamin D is best known for its role in developing strong bones, a number of studies have shown that low levels of the vitamin may predispose the body to high blood pressure, congestive heart failure, and chronic blood vessel inflammation (associated with hardening of the arteries).

Experimental studies have established a role for vitamin D metabolites in pathways that are integral to cardiovascular function and disease, including inflammation, thrombosis, and the renin–angiotensin system.

Signs of vitamin D deficiency can be hard to spot. Some people have no symptoms at all, while others experience aches and pains or feel more tired than usual.

Researchers say higher rates of vitamin D deficiency may be due in part to people spending more time indoors and efforts to minimize sun exposure through the use of sunscreens. Sunscreen with a sun protection factor (SPF) of 15 blocks approximately 99% of vitamin D synthesis by the skin.

People with vitamin D deficiency, which affects n estimate third to half of otherwise healthy people of middle age and older. Diet changes are an easy way to get more of the vitamin. Food sources of vitamin D include milk, fortified cereal, salmon, mackerel, sardines, and tuna. Sunshine is another source.
Vitamin D and heart disease

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